Details

Contract

Full-Time

Location

Singapore, Singapore

Department

Life Sciences

Openings

1

Job ID

34079101

Be a part of a revolutionary change. At PMI, we’ve chosen to do something incredible. We’re totally transforming our business, and building our future on smoke-free products with the power to improve the lives of a billion smokers worldwide. With huge change, comes huge opportunity. So, wherever you join us, you’ll enjoy the freedom to dream up and deliver better, brighter solutions and the space to move your career forward in endlessly different directions. It’s so rare in R&D that everything aligns to create the ideal conditions for outstanding work. Right now, at PMI, that’s exactly what’s happening. R&D is the driving force for our bold new vision: to replace cigarettes with a revolutionary portfolio of alternative products. Join us and you’ll have the resources, support and technology you need to break new ground and see ideas come to life. You’ll be surrounded by some of the brightest scientists in their fields, with fast access to subject experts and commercial decision-makers. If you’re creative, courageous and ready to take risks, you can make a huge impact and propel your career in an endless number of directions. Ultimately, by delivering our smoke-free future, your work could change the lives of a billion smokers. Your ‘day to day’ Lead a team of technicians responsible for the establishment and execution of in vitro toxicology and pharmacology studies. This will include regulatory in vitro toxicological assays such as microbial mutagenicity assays, as well as cell-based cytotoxicity and genotoxicity assays, in accordance with the OECD GLP requirements. The team will also be responsible for providing downstream cell and biochemical assay development, validation and analysis services to support the organization’s in vivo study execution, which includes a battery of clinical pathology assays, flow cytometry and ELISA assays. In addition, the Scientist - Cell Bioassays will lead the organizational effort in developing and implementing state-of-the-art organotypic cultures or organ-on-a-chip technology to advance the regulatory-compliant ready research capability in line with the 3Rs principle of animal research adopted by the organization. - Oversee the overall activities in the Cell Bioassays laboratories to ensure SOP/technical guides and training are available and adequate for the technicians to perform their day to day tasks. Ensure studies/test results are delivered in time, based on the study requirements and/or agreement with stakeholders; methods, equipment, systems and workflows are fit for purpose, up to date and efficient. - Responsible for establishing, maintaining and improving the organization’s technical expertise in the domain of in vitro toxicology and genotoxicology, keeping up with scientific and regulatory advancement in the field. This may include, but not be limited to microbial mutagenesis assay (Ames), cell-based viability assays (neutral red uptake) or mutagenesis assays (mouse lymphoma assay, micronucleus assay). - Keep track with technological advancement in the field, assess, adopt and provide expertise for developing and implementing new/innovative techniques, assays, methods, capabilities that will enable/accelerate organization’s scientific project portfolio execution and/or will meet external client needs. - Act as Study Director for in vitro toxicology and pharmacology studies, which includes being responsible for the overall scientific conduct of the study, from conceptualization to closure. Plans, manages and reports the studies in accordance with pertinent regulatory guidelines (i.e. OECD GLP Principles and Test Guidelines) and to customer's satisfaction. - Represent the function to coordinate and liaise with cross-functional units and stakeholders on the planning, resourcing, execution, data analysis and reporting of relevant study phase (i.e. clinical pathology, flow cytometry and biochemical assays) for in vivo pre-clinical studies. - Plan and conduct studies using project management tools and ensure timeline and budget are met; anticipate variations and provide information about changes on a timely basis. May have client facing opportunities. - Lead, develop and motivate the Cell Bioassays team, including performance management, technical and people leadership as well as learning and development. - Participate in establishing and maintaining an adequate, current and effective QMS system and assume ownership roles for the business area, systems, equipment and SOPs when applicable. Support quality/compliance inspections and audits conducted by both internal and external parties. Who we’re looking for - Postgraduate degree in Biology, Life Sciences or related scientific discipline, Ph.D. preferred. - At least 5 years of relevant professional experience, with in-depth scientific knowledge focusing on in vitro research and/or toxicology studies with a CRO, R&D unit within life science industry, or translational academic research organizations, preferably in a regulated environment. - Able to develop/optimize/validate cell-based and/or microbiological assays independently. - Experience in leading R&D team and projects. - Understanding of regulatory guidelines such as FDA, ICH, OECD GLP and TGs related to in vitro toxicology and genotoxicity, and quality management system is preferred. - Self-starter and highly motivated individual with excellent communication and influencing skills. What we offer Our success depends on the men and women who come to work every single day with a sense of purpose and an appetite for progress. Join PMI and you too can: - Seize the freedom to define your future and ours. We’ll empower you to take risks, experiment and explore. - Be part of an inclusive, diverse culture, where everyone’s contribution is respected; collaborate with some of the world’s best people and feel like you belong. - Pursue your ambitions and develop your skills with a global business – our staggering size and scale provides endless opportunities to progress. - Take pride in delivering our promise to society: to improve the lives of a billion smokers. If you believe you would be a good fit to the requirements of the role, please submit your application online. Only candidates who fit the hiring requirements will be contacted. The successful candidate will be hired on the local employment terms and conditions in Singapore. #LIjobs

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