Neuchatel, Switzerland


Life Sciences



Job ID


Manager In Vitro Alternatives – Neuchatel, Switzerland Be a part of a revolutionary change. At PMI, we’ve chosen to do something incredible. We’re totally transforming our business, and building our future on smoke-free products with the power to improve the lives of a billion smokers worldwide. We’re also exploring new categories, looking beyond nicotine to develop a new portfolio of innovative products. With huge change, comes huge opportunity. So, wherever you join us, you’ll enjoy the freedom to dream up and deliver better, brighter solutions and the space to move your career forward in endlessly different directions. It’s so rare in R&D that everything aligns to create the ideal conditions for outstanding work. Right now, at PMI, that’s exactly what’s happening. R&D is the driving force for our bold new vision: to replace cigarettes with a revolutionary portfolio of alternative products. Join us and you’ll have the resources, support and technology you need to break new ground and see ideas come to life. You’ll be surrounded by some of the brightest scientists in their fields, with fast access to subject experts and commercial decision-makers. If you’re creative, courageous and ready to take risks, you can make a huge impact and propel your career in an endless number of directions. Ultimately, by delivering our smoke-free and beyond nicotine future, your work could change the lives of millions. Your ‘day to day’ As the Manager of Alternative Methods, you will be accountable for directing a group of scientists and lab technicians to achieve the departmental objectives towards establishing new approach methodologies (NAMs) for better prediction of human responses while reducing animal testing for toxicological evaluation. You will be managing the in vitro activities involving human 3D cell culture models and advanced organ-on-a-chip systems. You will prepare a roadmap and adapt it to accommodate in vitro studies according to the needs of the Life Science Categories. You will ensure that the portfolio of test systems and methods are fit for the context of use for PMI's Toxicological Assessment. More specifically, you'll • Define, together with internal SMEs, short-, medium- and long-term cross-disciplinary strategies to advance the development of human physiologically relevant model systems, both internally and externally. • Identify New Approach Methodologies (NAMs) aimed at supporting 21st century toxicology initiative and, in collaboration with the Assay Development Team, plan, develop, establish, and validate the selected/prioritized in vitro assays and validate them according to validation requirements. • Manage and develop a portfolio of pre-clinical activities aimed at supporting the development of 21st century toxicology initiatives by leading and coordinating the activity of 3 units (Organotypic Tissue Models, Histology and Organ-on-a-chip) within the In Vitro Pharmacology (IVP) group. • Manage and develop a team of 4+ members including scientists and lab technicians. • Establish collaborations with experts in the field to keep abreast of the latest available technologies. Support innovation and exploration of novel cutting edge methods to optimize, improve and expand the laboratory assay/models portfolio. Increase laboratory performance by leading automation initiatives. • Represent the IVP group in project teams and pro-actively drive engagement with relevant internal and external key stakeholders. Generate presentations for project and leadership team meetings. Contribute to the writing/reviewing the scientific content of internal reports, conference abstracts/poster, manuscripts for publication in peer-reviewed scientific journals and to present PMI R&D research at international conferences and/or at R&D events. Who we’re looking for • MSc and/or PhD in relevant biology areas with a good track record of accomplishments developing physiologically relevant cellular systems and characterizing cellular responses. • Demonstrated knowledge in relevant biological areas including cell biology, toxicology and pharmacology. • Proficiency and hands-on experience with human cell culture and physiologically relevant test systems such as spheroids, organotypic cultures and organoids. • Experience with organ-on-a-chip and microfluidic systems. • Knowledge of tissue research methods such as histology, immunohistochemistry (IHC), immunofluorescence (IF) and in situ hybridization • Familiar with Adverse Outcome Pathway (AOP) concept and 3R principles. • Knowledge of cell-based assay validation requirements and standards. • Substantial experience leading a scientific research team in an academic or industry setting including leading projects, research teams and serving as a mentor. • Confirmed track record in leadership, ideally leading in a matrix organization with ability to generate results and align organizational resources to accomplish strategic objectives. • Excellent communication skills and ability to express complex concepts at all levels of the organization, encourage direct and open discussions, seek common ground to resolve conflicts. • Fluent, well written and spoken English is mandatory. What we offer Our success depends on the men and women who come to work every single day with a sense of purpose and an appetite for progress. Join PMI and you too can: • Seize the freedom to define your future and ours. We’ll empower you to take risks, experiment and explore. • Be part of an inclusive, diverse culture, where everyone’s contribution is respected; collaborate with some of the world’s best people and feel like you belong. • Pursue your ambitions and develop your skills with a global business – our staggering size and scale provides endless opportunities to progress. • Take pride in delivering our promise to society: to improve the lives of a billion smokers. #LIJobs